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Results PQQ protects against myocardial hypertrophy and fibrosis in a TAC-induced mouse model system Initially, a C57BL/6 mouse model of myocardial hypertrophy was established by using previously published protocols to perform the TAC procedure, with a subset of these mice being treated using PQQ (Figure 1A)

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Leukotriene C4 synthesis catalyzed by Dirofilaria immitis glutathione S-transferase [PMID: 2493201] Laboratory literature summary: Leukotriene C4 synthesis catalyzed by Dirofilaria immitis glutathione S-transferase