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What is the evidence for using thiamine, B12 (Vitamin B12), and magnesium in treating patients with Restless Legs Syndrome (RLS) and Periodic Limb Movement Disorder (PLMD)?

A.9.2.3 Classification is determined by expert judgment, on the basis of the weight of all evidence available including the guidance presented below

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Mechanisms of Action Nootropics do not act directly by releasing neurotransmitters or as receptor ligands [16], but improve the brain’s supply of glucose and oxygen, have antihypoxic effects, and protect brain tissue from neurotoxicity [9,17]