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Figure 1 MiR-15a and miR-16-1, which belong to the same cluster of tumor suppressor miRNAs, were found to be down-regulated both in GH-secreting and prolactin-secreting pituitary adenomas ( A group of miRNAs have been found to be downregulated in GH secreting adenomas leading to the overexpression of proteins involved in pituitary tumorigenesis