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R What Causes Methylation Impairment Alcohol (depletes folate, B12, B6, and directly inhibits methionine synthase) R Antibiotics (disrupt folate-producing gut bacteria) Chronic inflammation (inflammatory cytokines alter expression of methylation enzymes and increase SAM-e consumption) R Folic acid supplementation (synthetic folic acid must be reduced by DHFR, which has limited capacity
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