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According to a 2018 review in the journal Nutrients , “Recent Perspectives Regarding the Role of Dietary Protein for the Promotion of Muscle Hypertrophy with Resistance Exercise Training”: “While it is true that leucine is capable of stimulating MPS in the absence of other amino acids, it should be emphasized that protein synthesis will eventually become limited by the availability of other essential amino acids .” Another large meta-analysis, in which researcher Robert Wolfe reviewed all the available BCAA studies between 1985 and 2017, found exactly zero human studies in which BCAAs alone were responsible for more efficient muscle protein synthesis
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