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To determine the effect of NNMT inhibitor on NNMT activity in the pre-adipocytes and differentiated adipocytes (8×104 cells/well seeded prior to beginning differentiation), cells were treated with 30 μM inhibitor for 24 h
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The results showed that in patients taking IBRANCE and letrozole, tumor response was 55%—meaning more than half of these patients saw their tumors shrink in size —compared to 44% who took letrozole and placebo
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