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A renal substudy of the China Stroke Primary Prevention Trial (CSPPT) evaluated the effects of the combination of Angiotensin Converting Enzyme (ACE) inhibitors and folic acid with ACE inhibitors alone in reducing the risk of renal function decline in a hypertensive population without folic acid fortification

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or intragastrically i.g., respectively) prior to carbon tetrachloride (CCl 4 ) intoxication showed a significant drop in bilirubin and aspartate aminotransferase as compared to that of the control group