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Given the lack of change in cell densities, the observed tissue swelling is likely to be due to increased water content and oedema, which has been found to occur as early as 3 days into cuprizone exposure and continue to at least 5 weeks 58
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[DOI] [PubMed] [Google Scholar] 265.Keremi B., Lohinai Z., Komora P., Duhaj S., Borsi K., Jobbagy-Ovari G., Kallo K., Szekely A.D., Fazekas A., Dobo-Nagy C., et al