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SNP-specific F-statistics were calculated to evaluate the instrumental efficiency of SNPs with R 2 , exposure sample size, and the number of SNPs (Supplementary Table S1) ( Statistical analysis An inverse-variance weighted (IVW) analytical approach was applied to provide MR estimation and showed the largest statistical power among all MR methods by combining each Wald ratio of multiple SNPs ( 0

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In addition, OX40 is essential for CD8 + cytotoxic T cells, promoting the survival and proliferation of activated CD8 + T cells and enhancing their response to antigenic stimuli [213]