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Studies treating mild to moderate B12 deficiency in older people have failed to provide cognitive benefits: A clinical trial from the Netherlands measured the cognitive response to B12 supplements in people ≥70 years old with mild B12 deficiency and MMA levels ≥320 nmol/l (average: ~450 nmol/l)

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4.2.4 Allosteric inhibitors Allosteric inhibitors represent a class of inhibitors that do not compete for the SAM or NAM binding sites on NNMT

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