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In this 52-week trial, 47.2% of patients in the lorcaserin group lost at least 5% of their body weight, compared to 25% of patients in the placebo group [84]
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These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue.⁴ ⁵ Sodium and chloride ions screen the peptide’s positive charge, so the receptor sees less of it and the welt shrinks
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