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Ferroptosis Ethanol feeding results in iron-dependent ferroptotic cell death, which is characterized by excessive accumulation of intracellular lipid ROS and consequent lipid peroxidation resulting from depletion of iron-dependent glutathione and inactivation of glutathione peroxidase 4 (GPX4) (39)
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As such, VitC plays a number of important roles in reducing oxidative stress caused by infection, balancing the immune system, and killing microorganisms by generating free radicals
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