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(2021) pilot RCT, GlyNAC supplementation in older adults reduced HOMA-IR (a marker of insulin resistance) to levels comparable to younger controls [10]

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The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For