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Cagrilintide Dose Escalation Studies Phase 2 trials evaluated multiple cagrilintide doses to identify the optimal balance between efficacy and tolerability: 0.3 mg weekly – Minimal efficacy, excellent tolerability 0.6 mg weekly – Moderate effects, good tolerability 1.2 mg weekly – Strong efficacy, acceptable side effects 2.4 mg weekly – Optimal efficacy-tolerability balance 4.5 mg weekly – Excessive GI side effects outweighed benefits The 2.4 mg weekly dose emerged as the standard in phase 3 trials, providing substantial metabolic benefits while maintaining an acceptable side effect profile[6]

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We showed that senolysis of p21 high cells in human adipose ex vivo xenografted immunodeficient mice using a dasatinib + quercetin cocktail reduces insulin resistance [56]