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A 2020 preclinical safety evaluation (Xu et al., 2020, Regul Toxicol Pharmacol ) confirmed a favorable profile at research-relevant doses with no significant organ toxicity at tested concentrations

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Factors associated with anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein antibody titer and neutralizing activity among healthcare workers following vaccination with the BNT162b2 vaccine