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Elevated lactate concentrations have been demonstrated to increase the NADH/NAD+ ratio, leading to the inhibition of key glycolytic enzymes such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate dehydrogenase, ultimately suppressing both glycolysis and mitochondrial respiration (85)

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For information about other supplements that may help, see our answer to the question: Do any supplements, foods, or oils help reduce muscle pain, muscle cramps, or nighttime leg cramps