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To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamate–cysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen

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[PubMed] [Google Scholar] 6.Aruoma OI, Halliwell B, Hoey BM, et al